1. AI & ML
- The Transformer Model, Explained
- Understanding Categorical Cross-Entropy Loss, Binary Cross-Entropy Loss, Softmax Loss, Logistic Loss, Focal Loss and all those confusing names
- The Illustrated AlphaFold | matmols
- ML for protein structure prediction: AlphaFold2 architecture - YouTube
- The case for AGI by 2030 - 80,000 Hours
- Voice AI & Voice Agents | An Illustrated Primer
- Designing a robust reward function for FutureHouse’s ether0 model
- MOCs for learning AI/ML: 4-stage roadmap, ML Resources MOC, LLMs Visually Explained, Intro to Transformers
- The 2025 AI Engineering Reading List - Latent Space
- AI-Enabled Coups: How a Small Group Could Use AI to Seize Power
- Getting Started in Materials Informatics
- Deepchem
- Practical Cheminformatics · GitHub
- Liquid Neural Networks - YouTube
- Fetching Title#gcdg
2. Hardware, Computing, Algorithms
- A history of Nvidia’s Multiprocessors
- How does Computer Memory Work? - YouTube
- GPU Glossary
- Exploring How Computers Work - YouTube
- Algorithms for Modern Hardware - Algorithmica
- The Fancy Algorithms That Make Your Computer Feel Smoother - YouTube
- I Tried Putting my Fluid Simulation on a Planet - YouTube
3. Energy & Manufacturing
- Will We Ever Get Fusion Power?
- Deep-dive on the transition to clean energy
- Energy & Humanity
- 50 Things I’ve Learned Writing Construction Physics
- As Much As You Ever Wanted To Know About 155mm Artillery Shell Production and More
- Thermodynamics of Synthetic Fuels - by Andrew Cote
- Energy Density Comparison with Nuclear
4. Founder & Startup Advice
- List of Things Startups Did That Didn’t Scale
- Starter Guide to SF for Founders
- The 1517 Anti-Pitch Playbook
- The Founder’s Guide to the DOE
- Founder’s Handbook Notion Page
- Vertical Integrators - Not Boring by Packy McCormick
- The Heart of Innovation
- Founder Playlist | Playlist of Founder Advice from Pillar VC
- Capital Intensity Isn’t Bad - Not Boring by Packy McCormick
- Competition is for Losers with Peter Thiel - YouTube
- Brian Chesky - Founder Mode & The Art of Hiring - YouTube
- What You Should Know about Venture Capital - Google Slides
- The Investors’ Guide to the DOE
- SBIR/STTR Workshop: Application Process & Funding Options for Startups 4/22/2025 - YouTube
- Nail Your Raise: Luring VCs | Vinod Khosla - YouTube
- Rebuild the Arsenal and Palmer Luckey, American Vulcan
- List of Deeptech Companies
- Fifty Years Progress Map
- The Hidden Math of Churn
- Rayne Ong Session: The Founder’s Guide to Raising Capital NC - Google Docs
- Feedback Culture - by Nate Tucker - @natetucker
- Putting the Jobs to be Done Interview to Practice - Commoncog
5. Biology & Chemistry
- Living Carbon: Photosynthesis-Enhanced Trees
- Levers for Biological Progress - Progress Forum
- Will protein design tools solve the snake antivenom shortage?
- The Codon Guide to Synthetic Biology - Asimov Press
- A Visual Guide to Genome Editors - by Evan DeTurk
- Defeating a Virus That Killed Half a Billion People – The Plea - YouTube
- Hummingbird List of Biolabs
- A Billion Years of Evolution in a Single Afternoon — George Church - YouTube
- A new breed of biotech | Alex’s blog
- From Silicon to Slime | Are.na Editorial
- How to succeed in science: a concise guide for young biomedical scientists
- Arnold Kriegstein (UCSF) 1: Radial Glia Cells - YouTube
- Arnold Kriegstein (UCSF) 2: Cerebral Organoids - YouTube
- Your Review: Of Mice, Mechanisms, and Dementia
6. Physics & Math
- This Is the Calculus They Won’t Teach You - YouTube
- Moon – Bartosz Ciechanowski
- Quantum computing for the determined – Michael Nielsen
- Terence Tao on how we measure the cosmos | Part 1 - YouTube
- The things you’ll find in higher dimensions - YouTube
- Quantum Country
- A Visual, Intuitive Understanding of Bayes Theorem
- Entropy measures how little we know about the universe – Quanta Magazine
- Why Momentum Really Works
- The Story of Information Theory: from Morse to Shannon to ENTROPY - YouTube
7. Policy & Philosophy & Decision Making
- How to Build the Future of AI in the United States | IFP
- The Techno-Industrial Policy Playbook
- Kludgeocracy in America | National Affairs
- Inadequate Equilibria: Where and How Civilizations Get Stuck
- Effective action: Systems-engineering to systems-politics
- The Gentle Romance - by Richard Ngo - Asimov Press
- No, it’s not The Incentives—it’s you – [citation needed]
- In Search of Narrative Violations — Bedrock
8. Advice
- Advice for the ambitious: Part 1, Part 2, Part 3
- College advice for people who are exactly like me | benkuhn.net
- Searching for outliers | benkuhn.net
- Dr. R. W. Hamming’s Advice on Great Work and Paul Graham’s commentary
- Supplements | near.blog
- Double your productivity without more work or stress
- My colleague Julius
- Nonfiction Writing Advice
- Relationships @visakanv’s blog
- visakanv’s howto - Google Docs
- I Put a Toaster in the Dishwasher
- YOUTH - by Jared Young - Tolstoyan
- How to live an intellectually rich life - by Utsav Mamoria
- 1 Hour Breathwork
- Career Advice and Salary Negotiations – The HFT Guy
9. Learning and Knowledge
- The Math Academy Way
- The Best Reference Works for Every Subject — LessWrong
- The Best Textbooks on Every Subject — LessWrong
- The Best Tacit Knowledge Videos on Every Subject — LessWrong
- Tacit Knowledge Video: Studying Quantum Mechanics with Andy Matuschak - YouTube
- MOCS for learning other engineering: Pure Math Roadmap, EE Roadmap
- School Is Not Enough
- Behind the Scenes of My Interview Research Process — Andy Matuschak Crashes My Crib! - YouTube
- Timeful Texts
- How can we develop transformative tools for thought?
- GitHub - norvig/pytudes: Python programs, usually short, of considerable difficulty, to perfect particular skills.
- Augmenting Long-term Memory
10. Misc
- Neuralink Show and Tell, Fall 2022 - YouTube
- The Secret of Our Success | Joseph Henrich | Talks at Google - YouTube
- What Actually Improves Your Photos - Roman Fox
- CSIS Wargaming a Chinese Invasion of Taiwan - YouTube
- 13 Signs You Used ChatGPT To Write That
- Graham Duncan: Talent Whisperer - Colossus
- History of Philosophy
- Fuck Massages by Tony Fadell
- Reflections on OpenAI
To Learn
Leadership
- “Are You Destined to Deal?” With Goldman Sachs MD Jim Donovan - YouTube
- Leadership Lab: Writing Training - YouTube
- Personality 101 - YouTube
Biology
- MITx: Principles of Synthetic Biology | edX
- Syllabus - APh161
- Cell Biology by the Numbers and the videos Cell Biology By The Numbers - YouTube
- How to Design Plasmids: Benchling Tutorial - YouTube
Mathematics and Physics
- Matter and Energy - YouTube
- Oxford Student Lectures - Information Theory - YouTube
- Stanford’s Introduction to Probability - YouTube
- MIT OCW Probability + MIT OCW Problem Sets
- Matrix Methods + MIT 18.065 Videos
- Napkin Mathematics
- StatQuest with Josh Starmer - YouTube
- Gilbert Strang lectures on Linear Algebra (MIT) - YouTube
- Information Theory, Pattern Recognition, and Neural Networks - YouTube
- 6.041 Probabilistic Systems Analysis and Applied Probability - YouTube
- Resources | Poker Theory and Analytics | Sloan School of Management | MIT OpenCourseWare
- The Complete Mathematics of Neural Networks and Deep Learning - YouTube
- CIS5150
Programming
- Intuitive Mathematics of Machine Learning (Paid textbook for $70)
- Stanford CS229: Machine Learning
- Alpha for Learning GPUs
- Introduction to Probability for Computing
- Understanding Deep Learning
- CS 189/289A: Introduction to Machine Learning
AI-Guided Design of Proteins and other Biological Materials
- Rosetta Workshop 2024 – Meiler Lab
- Design of small molecule binding proteins using deep learning - YouTube
- Boltz-1 and the Future of Biomolecular Foundation Models - YouTube
- Intro to PyRosetta - Pose Basics - YouTube
- Dr. Lurong Pan | Protein LLM and Generative AI in Protein Engineering - YouTube
Electrical Engineering
- MIT OCW Signals and Systems
- MIT OCW Statistical Mechanics I
- MIT OCW Communication, Control, and Signal Processing
- Getting To Blinky KiCad Tutorial Series - YouTube
Misc