1. AI & ML

  1. The Transformer Model, Explained
  2. Understanding Categorical Cross-Entropy Loss, Binary Cross-Entropy Loss, Softmax Loss, Logistic Loss, Focal Loss and all those confusing names
  3. The Illustrated AlphaFold | matmols
  4. ML for protein structure prediction: AlphaFold2 architecture - YouTube
  5. The case for AGI by 2030 - 80,000 Hours
  6. Voice AI & Voice Agents | An Illustrated Primer
  7. Designing a robust reward function for FutureHouse’s ether0 model
  8. MOCs for learning AI/ML: 4-stage roadmap, ML Resources MOC, LLMs Visually Explained, Intro to Transformers
  9. The 2025 AI Engineering Reading List - Latent Space
  10. AI-Enabled Coups: How a Small Group Could Use AI to Seize Power
  11. Getting Started in Materials Informatics
  12. Deepchem
  13. Practical Cheminformatics · GitHub
  14. Liquid Neural Networks - YouTube
  15. Fetching Title#gcdg

2. Hardware, Computing, Algorithms

  1. A history of Nvidia’s Multiprocessors
  2. How does Computer Memory Work? - YouTube
  3. GPU Glossary
  4. Exploring How Computers Work - YouTube
  5. Algorithms for Modern Hardware - Algorithmica
  6. The Fancy Algorithms That Make Your Computer Feel Smoother - YouTube
  7. I Tried Putting my Fluid Simulation on a Planet - YouTube

3. Energy & Manufacturing

  1. Will We Ever Get Fusion Power?
  2. Deep-dive on the transition to clean energy
  3. Energy & Humanity
  4. 50 Things I’ve Learned Writing Construction Physics
  5. As Much As You Ever Wanted To Know About 155mm Artillery Shell Production and More
  6. Thermodynamics of Synthetic Fuels - by Andrew Cote
  7. Energy Density Comparison with Nuclear

4. Founder & Startup Advice

  1. List of Things Startups Did That Didn’t Scale
  2. Starter Guide to SF for Founders
  3. The 1517 Anti-Pitch Playbook
  4. The Founder’s Guide to the DOE
  5. Founder’s Handbook Notion Page
  6. Vertical Integrators - Not Boring by Packy McCormick
  7. The Heart of Innovation
  8. Founder Playlist | Playlist of Founder Advice from Pillar VC
  9. Capital Intensity Isn’t Bad - Not Boring by Packy McCormick
  10. Competition is for Losers with Peter Thiel - YouTube
  11. Brian Chesky - Founder Mode & The Art of Hiring - YouTube
  12. What You Should Know about Venture Capital - Google Slides
  13. The Investors’ Guide to the DOE
  14. SBIR/STTR Workshop: Application Process & Funding Options for Startups 4/22/2025 - YouTube
  15. Nail Your Raise: Luring VCs | Vinod Khosla - YouTube
  16. Rebuild the Arsenal and Palmer Luckey, American Vulcan
  17. List of Deeptech Companies
  18. Fifty Years Progress Map
  19. The Hidden Math of Churn
  20. Rayne Ong Session: The Founder’s Guide to Raising Capital NC - Google Docs
  21. Feedback Culture - by Nate Tucker - @natetucker
  22. Putting the Jobs to be Done Interview to Practice - Commoncog

5. Biology & Chemistry

  1. Living Carbon: Photosynthesis-Enhanced Trees
  2. Levers for Biological Progress - Progress Forum
  3. Will protein design tools solve the snake antivenom shortage?
  4. The Codon Guide to Synthetic Biology - Asimov Press
  5. A Visual Guide to Genome Editors - by Evan DeTurk
  6. Defeating a Virus That Killed Half a Billion People – The Plea - YouTube
  7. Hummingbird List of Biolabs
  8. A Billion Years of Evolution in a Single Afternoon — George Church - YouTube
  9. A new breed of biotech | Alex’s blog
  10. From Silicon to Slime | Are.na Editorial
  11. How to succeed in science: a concise guide for young biomedical scientists
  12. Arnold Kriegstein (UCSF) 1: Radial Glia Cells - YouTube
  13. Arnold Kriegstein (UCSF) 2: Cerebral Organoids - YouTube
  14. Your Review: Of Mice, Mechanisms, and Dementia

6. Physics & Math

  1. This Is the Calculus They Won’t Teach You - YouTube
  2. Moon – Bartosz Ciechanowski
  3. Quantum computing for the determined – Michael Nielsen
  4. Terence Tao on how we measure the cosmos | Part 1 - YouTube
  5. The things you’ll find in higher dimensions - YouTube
  6. Quantum Country
  7. A Visual, Intuitive Understanding of Bayes Theorem
  8. Entropy measures how little we know about the universe – Quanta Magazine
  9. Why Momentum Really Works
  10. The Story of Information Theory: from Morse to Shannon to ENTROPY - YouTube

7. Policy & Philosophy & Decision Making

  1. How to Build the Future of AI in the United States | IFP
  2. The Techno-Industrial Policy Playbook
  3. Kludgeocracy in America | National Affairs
  4. Inadequate Equilibria: Where and How Civilizations Get Stuck
  5. Effective action: Systems-engineering to systems-politics
  6. The Gentle Romance - by Richard Ngo - Asimov Press
  7. No, it’s not The Incentives—it’s you – [citation needed]
  8. In Search of Narrative Violations — Bedrock

8. Advice

  1. Advice for the ambitious: Part 1, Part 2, Part 3
  2. College advice for people who are exactly like me | benkuhn.net
  3. Searching for outliers | benkuhn.net
  4. Dr. R. W. Hamming’s Advice on Great Work and Paul Graham’s commentary
  5. Supplements | near.blog
  6. Double your productivity without more work or stress
  7. My colleague Julius
  8. Nonfiction Writing Advice
  9. Relationships @visakanv’s blog
  10. visakanv’s howto - Google Docs
  11. I Put a Toaster in the Dishwasher
  12. YOUTH - by Jared Young - Tolstoyan
  13. How to live an intellectually rich life - by Utsav Mamoria
  14. 1 Hour Breathwork
  15. Career Advice and Salary Negotiations – The HFT Guy

9. Learning and Knowledge

  1. The Math Academy Way
  2. The Best Reference Works for Every Subject — LessWrong
  3. The Best Textbooks on Every Subject — LessWrong
  4. The Best Tacit Knowledge Videos on Every Subject — LessWrong
  5. Tacit Knowledge Video: Studying Quantum Mechanics with Andy Matuschak - YouTube
  6. MOCS for learning other engineering: Pure Math Roadmap, EE Roadmap
  7. School Is Not Enough
  8. Behind the Scenes of My Interview Research Process — Andy Matuschak Crashes My Crib! - YouTube
  9. Timeful Texts
  10. How can we develop transformative tools for thought?
  11. GitHub - norvig/pytudes: Python programs, usually short, of considerable difficulty, to perfect particular skills.
  12. Augmenting Long-term Memory

10. Misc

  1. Neuralink Show and Tell, Fall 2022 - YouTube
  2. The Secret of Our Success | Joseph Henrich | Talks at Google - YouTube
  3. What Actually Improves Your Photos - Roman Fox
  4. CSIS Wargaming a Chinese Invasion of Taiwan - YouTube
  5. 13 Signs You Used ChatGPT To Write That
  6. Graham Duncan: Talent Whisperer - Colossus
  7. History of Philosophy
  8. Fuck Massages by Tony Fadell
  9. Reflections on OpenAI

To Learn

Leadership

Biology

Mathematics and Physics

Programming

AI-Guided Design of Proteins and other Biological Materials

Electrical Engineering

Misc